5 Skin Care Trends That Will Define 2026, According to Dermatologists

“Biologic therapies such as biostimulators, exosomes, platelet-rich fibrin (PRF), growth factors, and stem-cell-derived products are transforming rejuvenation by improving tissue quality from within,” she explains.

However, when it comes to exosomes, she cautions that they will only be highly effective when they remain stable and intact in the final formula. “Exosomes act as cellular messengers, carrying growth factors and proteins that support skin rejuvenation. If they break down during formulation, they can’t deliver those signals, meaning performance hinges on stability.”

Dr. Engelman recommends SkinMedica TNS Recovery Complex, which contains stable, fibroblast-derived exosomes that remain intact and active in the finished product. “This is the first peer-reviewed study of its kind, and it’s an important distinction because it validates that exosomes in this formula not only exist, but arrive to the skin in a state where they can actually perform,” she says.

Tailored injections

Another emerging trend is custom and tailored dosing of neurotoxins like Botox. “A top concern for patients is the fear of unnatural outcomes,” explains Dr. Engelman. “However, research shows that when done appropriately, and in the hands of licensed and trained providers, the outcome can be very desirable.”

Dr. Engelman also predicts that hyaluronic acid injectable fillers like Juvederm will remain a staple, albeit with a different role than years past. “As aesthetics matures, fillers aren’t being phased out; they’re being refined,” she says. “Their role is becoming less about dramatic transformation and more about quiet craftsmanship. In 2026 hyaluronic is the essential medium for a new generation of subtle, sophisticated results that no other technology can replicate. Patients aren’t asking to ‘get filled’; they’re asking to look like themselves, but fresher.”

As a result, filler is shifting toward “micro-dosing, layered refinement, and anatomy-respectful enhancement, rather than the volumizing approaches that defined the early 2020s.”

Biomimetic ingredients

Some of the biggest trends that will dominate skin care in 2026 are biomimetic ingredients (ingredients that mimic the substances that naturally occur in our skin and body), PDRN products, and products that combat any unwanted effects of using GLP-1s.